Rhabdomyolysis and Acute Kidney Injury Associated with Hypothyroidism and Statin Therapy
Endocrinology and Metabolism
; : 331-334, 2013.
Article
в En
| WPRIM
| ID: wpr-141174
Ответственная библиотека:
WPRO
ABSTRACT
Rhabdomyolysis is a syndrome involving the breakdown of skeletal muscle that causes myoglobin and other intracellular proteins to leak into the circulatory system, resulting in organ injury including acute kidney injury. We report a case of statin-induced rhabdomyolysis and acute kidney injury that developed in a 63-year-old woman with previously undiagnosed hypothyroidism. Untreated hypothyroidism may have caused her hypercholesterolemia requiring statin treatment, and it is postulated that statin-induced muscle injury was aggravated by hypothyroidism resulting in her full-blown rhabdomyolysis. Although this patient was successfully treated with continuous venovenous hemofiltration and L-thyroxin replacement, rhabdomyolysis with acute kidney injury is a potentially life-threatening disorder. Physicians must pay special attention to the possible presence of subclinical hypothyroidism when administering statins in patients with hypercholesterolemia.
Key words
Полный текст:
1
База данных:
WPRIM
Основная тема:
Rhabdomyolysis
/
Hemofiltration
/
Muscle, Skeletal
/
Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Acute Kidney Injury
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Hypercholesterolemia
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Hypothyroidism
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Muscles
/
Myoglobin
Пределы темы:
Female
/
Humans
Язык:
En
Журнал:
Endocrinology and Metabolism
Год:
2013
Тип:
Article