Pain Palliation in Patients with Bone Metastases Using Magnetic Resonance-Guided Focused Ultrasound with Conformal Bone System: A Preliminary Report
Yonsei Medical Journal
; : 503-509, 2015.
Article
в En
| WPRIM
| ID: wpr-141613
Ответственная библиотека:
WPRO
ABSTRACT
PURPOSE: We evaluated the safety and effectiveness of the Magnetic Resonance-guided Focused Ultrasound (MRgFUS) with the ExAblate Conformal Bone System for the palliation of painful bone metastases. MATERIALS AND METHODS: Our Institutional Review Board approved this study, and all patients gave informed consent prior to enrollment. A total of six painful metastatic bone lesions in five patients were treated using MRgFUS with the ExAblate Conformal Bone System for pain palliation. The follow-up sessions were at 3 days, 2 weeks, 1, 2, and 3 months, and 1 year after treatment. Efficacy was evaluated by the changes in visual analog scale (VAS) scores. At 3-months and 1-year follow-ups, unenhanced computed tomography and contrast-enhanced MR imaging examinations were performed. All adverse events were assessed to evaluate treatment safety. RESULTS: All patients showed significant pain relief within 2 weeks. Two patients experienced complete pain reduction that lasted for 1 year. Two other patients showed pain relief measured as VAS scores of 2 and 4 on their last follow-up. Although the remaining patient had experienced significant pain relief in two lesions, the VAS score re-increased on his last follow-up. The size of the enhancing soft tissue mass in metastatic lesions decreased, and new bone formation was seen on follow-up images. Although adverse events were not serious, non-specific leg pain and second degree skin burn were noted. CONCLUSION: MRgFUS was demonstrated to be effective palliative treatment within 2 weeks in selected patients with painful bone metastases.
Key words
Полный текст:
1
База данных:
WPRIM
Основная тема:
Pain
/
Palliative Care
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Bone Neoplasms
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Magnetic Resonance Spectroscopy
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Tomography, X-Ray Computed
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Prospective Studies
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Treatment Outcome
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Contrast Media
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Magnetic Resonance Imaging, Interventional
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High-Intensity Focused Ultrasound Ablation
Тип исследования:
Observational_studies
Пределы темы:
Adult
/
Aged
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Female
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Humans
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Male
Язык:
En
Журнал:
Yonsei Medical Journal
Год:
2015
Тип:
Article