Clinicopathologic characteristics of granulosa cell tumors of the ovary: a multicenter retrospective study / 부인종양
Journal of Gynecologic Oncology
; : 188-195, 2011.
Article
в En
| WPRIM
| ID: wpr-150980
Ответственная библиотека:
WPRO
ABSTRACT
OBJECTIVE: To evaluate the clinicopathologic characteristics and prognostic factors of ovarian granulosa cell tumors. METHODS: Medical records of 113 patients presenting between January 1995 and December 2007 were retrospectively reviewed. RESULTS: One-hundred two patients had adult type disease, with a mean age of 46.2 years (range, 18 to 83 years) and a mean follow-up period of 54.7 months (range, 1 to 155 months). The distribution of FIGO stages was 86 patients at stage I, 11 at stage II, and 5 at stage III. During follow-up, ten patients recurred at a mean time of 48 months (range, 4 to 109 months). Among them, three patients died after a mean of 57 months (range, 25 to 103 months). In recurrence analysis, advanced stage (p=0.032) and presence of residual disease (p=0.012) were statistically significant, and age<40 years, premenopause and positive washing cytology were marginally significant (p<0.1). In multivariate analysis, stage was the only factor associated with recurrence; adjuvant chemotherapy and fertility-sparing surgery were not statistically significant. Among 36 patients with fertility-sparing operations, eight patients had nine pregnancies and delivered seven babies. Eleven patients had juvenile type tumors; the mean age was 20.0 years (range, 8 to 45 years) and the mean follow-up period was 69.8 months (range, 20 to 156 months). The distribution of FIGO stage was nine patients at stage I and two at stage III. There were no recurrences or deaths reported. Four patients had seven pregnancies and delivered six babies. CONCLUSION: Stage is the only factor associated with disease-free survival, and fertility-sparing surgery may be a treatment option for women with early-stage disease who want to retain fertility.
Key words
Полный текст:
1
База данных:
WPRIM
Основная тема:
Ovary
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Recurrence
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Medical Records
/
Multivariate Analysis
/
Retrospective Studies
/
Follow-Up Studies
/
Chemotherapy, Adjuvant
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Premenopause
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Disease-Free Survival
/
Fertility
Тип исследования:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Пределы темы:
Adult
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Female
/
Humans
/
Pregnancy
Язык:
En
Журнал:
Journal of Gynecologic Oncology
Год:
2011
Тип:
Article