Recent Chemotherapy Reduces the Maximum-Standardized Uptake Value of 18F-Fluoro-Deoxyglucose Positron Emission Tomography in Colorectal Cancer
Gut and Liver
; : 254-264, 2014.
Article
в En
| WPRIM
| ID: wpr-163243
Ответственная библиотека:
WPRO
ABSTRACT
BACKGROUND/AIMS: The aim of this study was to evaluate the influence of recent chemotherapy on the patterns of the maximum-standardized uptake value (M-SUV) and sensitivity of 18F-fluoro-deoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) in colorectal cancer. METHODS: We retrospectively analyzed the FDG-PET/CT of 509 patients who underwent surgery for colorectal cancer. Subgroup analysis was performed according to chemotherapy status; 401 patients were not treated with chemotherapy and 108 patients were treated with chemotherapy within 6 months prior to surgery. Pathologic analysis of the surgical specimen was used as the gold standard. RESULTS: The M-SUV was significantly lower in patients treated with chemotherapy than in those not treated with chemotherapy in pathologically confirmed same stages of disease. The difference in the sensitivity of the M-SUV according to chemotherapy status was greatest using a cutoff M-SUV value of 6.4 (p<0.001). The longest diameter of the primary tumor was the most important factor that correlated with M-SUV of the primary tumor irrespective of the chemotherapy effect (p<0.001). The M-SUV of the primary tumor was not an independent predictor of lymph node metastasis in colorectal cancer. CONCLUSIONS: The results indicate that the M-SUV of FDG-PET/CT should be interpreted in the context of concurrent chemotherapy.
Key words
Полный текст:
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База данных:
WPRIM
Основная тема:
Colorectal Neoplasms
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Retrospective Studies
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Chemotherapy, Adjuvant
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Radiopharmaceuticals
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Fluorodeoxyglucose F18
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Positron-Emission Tomography
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Chemoradiotherapy, Adjuvant
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Neoplasm Invasiveness
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Neoplasm Metastasis
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Antineoplastic Agents
Тип исследования:
Observational_studies
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Prognostic_studies
Пределы темы:
Aged
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Female
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Humans
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Male
Язык:
En
Журнал:
Gut and Liver
Год:
2014
Тип:
Article