Retrospective Analysis on the Effects of House Dust Mite Specific Immunotherapy for More Than 3 Years in Atopic Dermatitis
Yonsei Medical Journal
; : 393-398, 2016.
Article
в En
| WPRIM
| ID: wpr-21017
Ответственная библиотека:
WPRO
ABSTRACT
PURPOSE:
In extrinsic atopic dermatitis (AD), house dust mites (HDM) play a role in eliciting or aggravating allergic lesions. The nature of skin inflammation in AD has raised a growing interest in allergen-specific immunotherapy (SIT). Thus, we assessed clinical improvement and laboratory parameters for evaluation of the benefit of long-term SIT. MATERIALS ANDMETHODS:
A total of 217 AD patients who were treated with SIT for at least 3 years were retrospectively assessed, by using their investigator global assessment, pruritus scores, loss of sleep (LOS), total serum IgE, and eosinophil counts collected. Patients were additionally classified into subgroups according to age, initial AD severity and mono- or multi-sensitization to include different individual factors in the evaluation of SIT efficacy. Lastly, we compared laboratory data of good responders to SIT with that of poor responders to SIT.RESULTS:
Improvement after SIT therapy was observed in 192 out of 217 patients (88.4%). Among these patients, 138 (63.5%) achieved excellent, near-complete or complete clinical remission. Significant reduction of pruritus, LOS, and the mean value of total serum IgE were observed (p0.05).CONCLUSION:
We emphasize the usefulness of long-term HDM SIT as a disease-modifying therapy for AD.Key words
Полный текст:
1
База данных:
WPRIM
Основная тема:
Severity of Illness Index
/
Allergens
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Retrospective Studies
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Desensitization, Immunologic
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Treatment Outcome
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Pyroglyphidae
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Dermatitis, Atopic
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Dose-Response Relationship, Drug
Тип исследования:
Observational_studies
Пределы темы:
Animals
/
Female
/
Humans
/
Male
Язык:
En
Журнал:
Yonsei Medical Journal
Год:
2016
Тип:
Article