A human papillomavirus (HPV)-16 or HPV-18 genotype is a reliable predictor of residual disease in a subsequent hysterectomy following a loop electrosurgical excision procedure for cervical intraepithelial neoplasia 3 / 부인종양
Journal of Gynecologic Oncology
; : e2-2016.
Article
в En
| WPRIM
| ID: wpr-21464
Ответственная библиотека:
WPRO
ABSTRACT
OBJECTIVE: This study was conducted using the human papillomavirus (HPV) DNA chip test (HDC), in order to determine whether the HPV genotype is a predictor of residual disease in a subsequent hysterectomy following a loop electrosurgical excision procedure (LEEP) for cervical intraepithelial neoplasia (CIN) 3. METHODS: Between January 2002 and February 2015, a total of 189 patients who underwent a hysterectomy within 6 months of LEEP caused by CIN 3 were included in this study. We analyzed their epidemiological data, pathological parameters, high-risk HPV (HR-HPV) load as measured by the hybrid capture II assay, and HR-HPV genotype as measured by the HDC. A logistic regression model was used to analyze the relationship between covariates and the probability of residual disease in subsequent hysterectomy specimens. RESULTS: Of the 189 patients, 92 (48.7%) had residual disease in the hysterectomy specimen, CIN 2 in seven patients, CIN 3 in 79 patients, IA1 cancer in five patients, and IA2 cancer in one patient. Using multivariate analysis, the results were as follows: cone margin positivity (odds ratio [OR], 2.43; 95% CI, 1.18 to 5.29; p or =220 relative light unit (OR, 2.98; 95% CI, 1.38 to 6.43; p<0.01), positive endocervical cytology (OR, 8.97; 95% CI, 3.81 to 21.13; p<0.001), and HPV-16 or HPV-18 positivity (OR, 9.07; 95% CI, 3.86 to 21.30; p<0.001). CONCLUSION: The HPV-16 or HPV-18 genotype is a reliable predictive factor of residual disease in a subsequent hysterectomy following a LEEP for CIN 3.
Key words
Полный текст:
1
База данных:
WPRIM
Основная тема:
Prognosis
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Uterine Cervical Dysplasia
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Uterine Cervical Neoplasms
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Retrospective Studies
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Neoplasm, Residual
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Viral Load
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Papillomavirus Infections
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Electrosurgery
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Human papillomavirus 16
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Human papillomavirus 18
Тип исследования:
Observational_studies
/
Prognostic_studies
Пределы темы:
Adult
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Aged
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Aged80
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Female
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Humans
Язык:
En
Журнал:
Journal of Gynecologic Oncology
Год:
2016
Тип:
Article