A new radiopharmaceutical for bone imaging: experimental study of 99mTc-HEDTMP / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 811-815, 2010.
Article
в Zh
| WPRIM
| ID: wpr-230779
Ответственная библиотека:
WPRO
ABSTRACT
The purpose of this study is to prepare 99mTc-HEDTMP [N-(2-hydroxyethyl) ethlenediamine-1,1,2-tri (methylene phosphonic acid), a new kind of bone seeking compound; to investigate its biological properties; and to explore the possibility of using it as a potential radiopharmaceutical for skeleton scintigraphy. HEDTMP was labeled with 99mTc by "pretinning" method, the radiochemical purity was 97.00% +/- 0.34%. 99mTc-HEDTMP was found to be stable in 5 hours in vitro with the radiochemical purity over 95% even after being diluted by physiological saline with the factor of dilution 100. The plane bone scanning of rabbits showed that 99mTc-HEDTMP was principally absorbed by skeletal system. Skull, spine and legs could be observed clearly, and were more legible than the images of 99mTc-MDP. Mice trial also indicated the high bone seeking of 99mTc-HEDTMP. The skeletal uptake was 11.92% ID/g, 13.19% ID/g, 10.14% ID/g, 10.04% ID/g, 7.71% ID/g separately at 30 minutes, 1 hour, 3 hours, 6 hours and 24 hours after the injection. Kidney seemed to be the major excretory organ. The clearance of blood was quick and the retaining amount in non-target organs was small. These results indicate that 99mTc-HEDTMP can be prepared easily, and its biological properties can be compared favorably with the commonly used bone imaging agent, and it is well worth further researching as a promising potential radiopharmaceutical in nuclide diagnosis for skeleton diseases.
Полный текст:
1
База данных:
WPRIM
Основная тема:
Bone and Bones
/
Diagnostic Imaging
/
Pharmacokinetics
/
Tissue Distribution
/
Random Allocation
/
Organotechnetium Compounds
/
Tomography, Emission-Computed, Single-Photon
/
Technetium Tc 99m Medronate
/
Radiopharmaceuticals
/
Metabolism
Тип исследования:
Diagnostic_studies
Пределы темы:
Animals
Язык:
Zh
Журнал:
Journal of Biomedical Engineering
Год:
2010
Тип:
Article