Changes in T cell subsets in children with sepsis, and their clinical significance / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 216-218, 2013.
Article
в Zh
| WPRIM
| ID: wpr-236835
Ответственная библиотека:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe changes in T cell subsets in children with sepsis and their prognosis, and to investigate the clinical significance of these changes in the occurrence and development of sepsis.</p><p><b>METHODS</b>Fifty children with severe sepsis and 150 children with general sepsis were enrolled as subjects, and 50 age-matched healthy children were included as controls. The percentages of CD3(+), CD4(+) and CD8(+) T cells in peripheral blood and CD4(+)/CD8(+) ratio were measured by flow cytometry. The pediatric critical illness score (PCIS) was calculated within 24 hours of admission.</p><p><b>RESULTS</b>The children with severe sepsis showed significantly lower percentages of CD3(+), CD4(+) and CD8(+) T cells CD4(+)/CD8(+) ratio and PCIS than the controls and children with general sepsis (P<0.01). Among the 200 cases of sepsis, the percentages of CD3(+), CD4(+) and CD8(+) T cells, CD4(+)/CD8(+) ratio and PCIS were significantly lower in the cured group than in the deceased group.</p><p><b>CONCLUSIONS</b>Children with sepsis have different degrees of cellular immunosuppression, and the degree of cellular immunosuppression is significantly correlated with the severity of the disease. Detection of T cell subsets in peripheral blood is of great significance for evaluating immune function and judging disease severity in children with sepsis.</p>
Полный текст:
1
База данных:
WPRIM
Основная тема:
Prognosis
/
T-Lymphocyte Subsets
/
CD4-CD8 Ratio
/
Sepsis
/
Allergy and Immunology
Тип исследования:
Prognostic_studies
Пределы темы:
Child, preschool
/
Female
/
Humans
/
Male
Язык:
Zh
Журнал:
Chinese Journal of Contemporary Pediatrics
Год:
2013
Тип:
Article