Synthesis and HIV-1 inhibitory activity of natural products isolated from Gnetum parvifolium and their analogues / 药学学报
Acta Pharmaceutica Sinica
; (12): 1509-1515, 2010.
Article
в Zh
| WPRIM
| ID: wpr-250602
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ABSTRACT
Resveratrol, isorhapontigenin and pinosylvin, isolated from Gnetum parvifolium, and their analogues have been synthesized and tested for their inhibitory activity of HIV-1. Natural product 12a and analogues (12d, 12e, 12g) display significant inhibitory activity of HIV-1 replication. Among them, compound 12d (trans-3, 4, 5, 4'-tetrahydroxystilbene) exhibits the most potent anti-HIV-1 activity with an IC50 value of 1.84 micromol x L(-1).
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1
База данных:
WPRIM
Основная тема:
Pharmacology
/
Physiology
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Plants, Medicinal
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Stilbenes
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Virology
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Virus Replication
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Drugs, Chinese Herbal
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Leukocytes, Mononuclear
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Molecular Structure
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Cells, Cultured
Язык:
Zh
Журнал:
Acta Pharmaceutica Sinica
Год:
2010
Тип:
Article