Microalbuminuria is Independently Associated with Arterial Stiffness and Vascular Inflammation but not with Carotid Intima-Media Thickness in Patients with Newly Diagnosed Type 2 Diabetes or Essential Hypertension
Journal of Korean Medical Science
; : 252-260, 2013.
Article
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| ID: wpr-25350
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ABSTRACT
The association between microalbuminuria (MAU) and the indices of macrovascular complication in patients with newly diagnosed type 2 diabetes (D) or essential hypertension (H) was evaluated. Total 446 patients were classified into four groups according to the urinary albumin-to-creatinine ratio MAU-D (n = 104), normoalbuminuria (NAU)-D (n = 114), MAU-H (n = 116), and NAU-H (n = 112). The indices of macrovascular complication including arterial stiffness evaluated by pulse-wave-velocity (PWV), carotid intima-media thickness (IMT), and vascular inflammation marked by high-sensitivity C-reactive protein (hsCRP) were assessed. PWV, IMT, and hsCRP were higher in patients with MAU than in those with NAU in both diabetes and hypertension groups. In both MAU-D and MAU-H groups, PWV and hsCRP levels were positively correlated with MAU level (MAU-D r = 0.47, 0.41, MAU-H r = 0.36, 0.62, respectively, P < 0.05). Additionally, PWV and hsCRP were independent factors predicting MAU (diabetes group OR 1.85, 1.54, hypertension group OR 1.38, 1.51, respectively, P < 0.001), but not IMT. MAU is independently associated with arterial stiffness and vascular inflammation but not with IMT in patients with newly diagnosed type 2 diabetes or essential hypertension, which emphasizes the importance of proactive clinical investigations for atherosclerotic complications in patients with MAU, even in newly diagnosed diabetes or hypertension.
Key words
Полный текст:
1
База данных:
WPRIM
Основная тема:
C-Reactive Protein
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Cardiovascular Diseases
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Logistic Models
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Odds Ratio
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Multivariate Analysis
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Risk Factors
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Area Under Curve
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Creatinine
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Diabetes Mellitus, Type 2
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Albuminuria
Тип исследования:
Diagnostic_studies
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Etiology_studies
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Prognostic_studies
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Risk_factors_studies
Пределы темы:
Female
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Humans
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Male
Язык:
En
Журнал:
Journal of Korean Medical Science
Год:
2013
Тип:
Article