Establishing aplastic anemia animal model based on different pathogenesis / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 285-289, 2015.
Article
в Zh
| WPRIM
| ID: wpr-259598
Ответственная библиотека:
WPRO
ABSTRACT
Aplastic anemia(AA) is a disease,including congenital AA and acquired AA, characterized by an extremely hypocellular marrow and peripheral blood pancytopenia due to bone marrow failure. Congenital AA is a autosomal recessive disease due to gene mutation. Persently, acquired AA is recognized as a disease caused by destruction of hematopoietic stem cells, defective marrow microenvironment and aberrant T cellular-immunity. In order to further study its pathogenesis and to choose effective therapeutic target, it has important clinical significance to establish correspondent animal model based on different pathogenesis. This article summarizes the congenital AA amimal models including Fanc A(-/-) mouse, Fanc C(-/-) mouse, Fanc G(-/-) mouse, Fanc D1(-/-)/Fanc 2(-/-) mouse, Fanc D2(-/-) mouse and other gene deficiency mouse AA models, and the acguired AA models resulting from the hematopoietic stem cell decrease, hematopoietic microenvironment injury, immune mediation and combination of hematopoietic stem cell dicrease with immune mediation.
Полный текст:
1
База данных:
WPRIM
Основная тема:
Pancytopenia
/
Bone Marrow
/
Hematopoietic Stem Cells
/
Disease Models, Animal
/
Anemia, Aplastic
Тип исследования:
Etiology_studies
Пределы темы:
Animals
Язык:
Zh
Журнал:
Journal of Experimental Hematology
Год:
2015
Тип:
Article