Quantity and apoptosis-related protein level of B lymphocyte in patients with immunorelated pancytopenia / 中华血液学杂志
Chinese Journal of Hematology
; (12): 236-238, 2002.
Article
в Zh
| WPRIM
| ID: wpr-261442
Ответственная библиотека:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To examine the quantity and apoptosis-related protein level of B lymphocyte in the patients with immunorelated pancytopenia (IRP) and explore the role of B lymphocyte in the pathogenetic mechanism of IRP.</p><p><b>METHODS</b>Quantities of all B lymphocytes and CD(5)(+) B lymphocytes and the expressions of Fas and bcl-2 on B lymphocytes in 25 patients with untreated IRP, 15 IRP patients in complete remission (CR) and 10 normal controls were assayed by FACS.</p><p><b>RESULTS</b>The percentages of B lymphocyte and CD(5)(+) B lymphocytes were significantly higher in untreated IRP patients than in CR IRP patients and normal controls (P < 0.05); there was no significant difference between the latter two groups (P > 0.05). There was no significant difference of Fas expression in B lymphocytes among the three groups (P > 0.05). The expression of bcl-2 on B lymphocytes was significantly higher in untreated patients than in CR patients or normal controls (P < 0.05), and so did in CR patients than in normal controls (P < 0.01). The apoptosis-related index was significantly lower in untreated patients than in CR patients or normal controls (P < 0.01), and was lower in CR patients than in normal controls (P < 0.05). The percentage of B lymphocyte was positively correlated with the duration from the beginning of treatment to response.</p><p><b>CONCLUSION</b>The production of auto-antibodies in IRP patients probably has some relationships with the abnormal quantities of B lymphocyte and its subsets, and with the inhibition of B lymphocyte apoptosis.</p>
Полный текст:
1
База данных:
WPRIM
Основная тема:
Pancytopenia
/
Pathology
/
Physiology
/
Bone Marrow
/
B-Lymphocytes
/
Cell Count
/
Classification
/
Apoptosis
/
Fas Receptor
/
CD5 Antigens
Пределы темы:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Язык:
Zh
Журнал:
Chinese Journal of Hematology
Год:
2002
Тип:
Article