Pharmacokinetics of osthole in rabbits / 药学学报
Acta Pharmaceutica Sinica
; (12): 571-573, 2003.
Article
в Zh
| WPRIM
| ID: wpr-266635
Ответственная библиотека:
WPRO
ABSTRACT
<p><b>AIM</b>To investigate the pharmacokinetics of osthole in rabbits and obtain the main pharmacokinetic parameters.</p><p><b>METHODS</b>A simple high-performance liquid chromatography (HPLC) method was developed to study the pharmacokinetics of osthole in rabbits by joining an internal standard (paeonal). Methanol-water (80:20) was used as the mobile phase. According to the 3P87 pharmacokinetic program, the main parameters were calculated.</p><p><b>RESULTS</b>The osthole pharmacokinetics conforms to a two compartment open model after i.v. administration, T1/2 alpha = 5.81 min, T1/2 beta = 42.2 min, K21 = 0.036 0.min-1, K12 = 0.045 0.min-1, K10 = 0.054 0.min-1, AUC = 235 mg.min.L-1, CLs = 0.043 0 L.min-1.kg-1, Vc = 0.780 L.kg-1.</p><p><b>CONCLUSION</b>The pharmacokinetics of osthole after i.v. administration showed a rapid distribution and elimination process in rabbits.</p>
Полный текст:
1
База данных:
WPRIM
Основная тема:
Plants, Medicinal
/
Blood
/
Pharmacokinetics
/
Calcium Channel Blockers
/
Metabolic Clearance Rate
/
Tissue Distribution
/
Chemistry
/
Chromatography, High Pressure Liquid
/
Area Under Curve
/
Coumarins
Тип исследования:
Prognostic_studies
Пределы темы:
Animals
Язык:
Zh
Журнал:
Acta Pharmaceutica Sinica
Год:
2003
Тип:
Article