Pharmacokinetic model for the enterohepatic circulation of mycophenolic acid / 药学学报
Acta Pharmaceutica Sinica
; (12): 272-276, 2006.
Article
в Zh
| WPRIM
| ID: wpr-271461
Ответственная библиотека:
WPRO
ABSTRACT
<p><b>AIM</b>To develop a pharmacokinetic model for the enterohepatic circulation of mycophenolic acid (MPA).</p><p><b>METHODS</b>Twenty healthy volunteers were orally given a single dose of 500 mg mycophenolate mofetil. Plasma samples were collected during 48 hours and MPA concentration was measured by HPLC method. Pharmacokinetic (PK) model was established based on physiological and biopharmaceutical consideration and PK parameters were obtained using nonlinear mixed effect model.</p><p><b>RESULTS</b>The proposed model included an intestinal compartment and gall bladder compartment in addition to the central compartment. The predicted time-concentration curve and AUC0-t, Cmax, Tmax estimated by the established model were in agreement with the observations.</p><p><b>CONCLUSION</b>The established model was well defined for the MPA disposition and could afford a useful approach for the further clinical investigation.</p>
Полный текст:
1
База данных:
WPRIM
Основная тема:
Physiology
/
Blood
/
Pharmacokinetics
/
Area Under Curve
/
Glucuronides
/
Enterohepatic Circulation
/
Immunosuppressive Agents
/
Models, Biological
/
Mycophenolic Acid
Тип исследования:
Prognostic_studies
Пределы темы:
Adult
/
Humans
/
Male
Язык:
Zh
Журнал:
Acta Pharmaceutica Sinica
Год:
2006
Тип:
Article