Correlation between Intravoxel Incoherent Motion Magnetic Resonance Imaging Derived Metrics and Serum Soluble CD40 Ligand Level in an Embolic Canine Stroke Model
Korean Journal of Radiology
; : 835-843, 2017.
Article
в En
| WPRIM
| ID: wpr-27514
Ответственная библиотека:
WPRO
ABSTRACT
OBJECTIVE:
To determine the relationship between intravoxel incoherent motion (IVIM) imaging derived quantitative metrics and serum soluble CD40 ligand (sCD40L) level in an embolic canine stroke model. MATERIALS ANDMETHODS:
A middle cerebral artery occlusion model was established in 24 beagle dogs. Experimental dogs were divided into low- and high-sCD40L group according to serum sCD40L level at 4.5 hours after establishing the model. IVIM imaging was scanned at 4.5 hours after model establishment using 10 b values ranging from 0 to 900 s/mm². Quantitative metrics diffusion coefficient (D), pseudodiffusion coefficient (D*), and perfusion fraction (f) of ischemic lesions were calculated. Quantitative metrics of ischemic lesions were normalized by contralateral hemisphere using the following formula normalized D = D(stroke) / D(contralateral). Differences in IVIM metrics between the low- and high-sCD40L groups were compared using t test. Pearson's correlation analyses were performed to determine the relationship between IVIM metrics and serum sCD40L level.RESULTS:
The high-sCD40L group showed significantly lower f and normalized f values than the low-sCD40L group (f, p 0.05). Both f and normalized f values were negatively correlated with serum sCD40L level (f, r = −0.789, p 0.05).CONCLUSION:
The f value derived from IVIM imaging was negatively correlated with serum sCD40L level. f value might serve as a potential imaging biomarker to assess the formation of microvascular thrombosis in hyperacute period of ischemic stroke.Key words
Полный текст:
1
База данных:
WPRIM
Основная тема:
Perfusion
/
Thrombosis
/
Magnetic Resonance Imaging
/
Stroke
/
Infarction, Middle Cerebral Artery
/
CD40 Ligand
/
Diffusion
Тип исследования:
Prognostic_studies
Пределы темы:
Animals
Язык:
En
Журнал:
Korean Journal of Radiology
Год:
2017
Тип:
Article