Effect of cucurmosin on chronic myeloid leukemia K562 cell line / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 891-894, 2013.
Article
в Zh
| WPRIM
| ID: wpr-284014
Ответственная библиотека:
WPRO
ABSTRACT
This study was aimed to investigate the antitumor effect of pumpkin protein (cucurmosin, CUS) on subcutaneous transplant tumor in chronic myeloid leukemia K562 cell-NOD/SCID mice and leukemia model. The subcutaneous transplant tumor in K562-NOD/SCID mice and leukemia model were established; using two models, the antitumor activity of CUS in mice was evaluated. The results indicated that the inhibitory rate of 0.5 mg/kg and 1 mg/kg CUS on subcutaneous transplant tumor were 53.45% and 59.43% respectively; survival time of mice received 0.25 mg/kg and 0.5 mg/kg CUS was 39.8 ± 5.5 d and 43.4 ± 6.6 d, antitumor rate was 24.9% and 36% respectively. It is concluded that CUS has significant inhibitory effect on mice with CML cell line K562.
Полный текст:
1
База данных:
WPRIM
Основная тема:
Pathology
/
Pharmacology
/
Plant Proteins
/
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
/
Mice, SCID
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Mice, Inbred NOD
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K562 Cells
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Xenograft Model Antitumor Assays
/
Drug Therapy
Пределы темы:
Animals
/
Female
/
Humans
Язык:
Zh
Журнал:
Journal of Experimental Hematology
Год:
2013
Тип:
Article