Effects of Sarcandra glabra extract on immune activity in restraint stress mice / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the protective effect of Sarcandra glabra extract (SGE) on immune system in restrained mice.</p><p><b>METHOD</b>The male C57BL/6 mice were randomly divided into normal control group, stress control group, 125, 500 mg x kg(-1) SGE group. The spleen lymphocyte suspensions of each group were prepared. The parameters of spleen T cells subsets, NK cell and NKT cell proportion and number was detected by Flow cytometry.</p><p><b>RESULT</b>SGE regulated the balance of T cell subsets, increased the percent of NK cells and NKT cell proportion and number in restrained mice.</p><p><b>CONCLUSION</b>SGE has immunologic protective effect in restrained mice probably via the amelioration of immune cells proportion and number.</p>