Effects of tanycytes transplantation on the motor function score and rubrospinal motor evoked potentials of adult rats after spinal cord completely transected / 中国应用生理学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To determine whether tanycytes be able to support the regeneration of completely transected spinal cord in adult rats.</p><p><b>METHODS</b>Subcultured tanycytes was transplanted into completely T8 transected spinal cord using the untranslated completely transected rats as control. After transplantation the rubrospinal motor evoked potentials were recorded below the injury level at the end of 12th week, assistant by Basso-Beatie-Bresnahan locomotor rating scale and histology method.</p><p><b>RESULTS</b>At the end of 12th week the total peak amplitude of rubrospinal motor evoked potentials (MD = 133.2 microV, P < 0.01) and BBB locomotor rating scale (MD = 5.0000, P < 0.01) were both significantly improved in cell transplanted group compared with that in the untranslated control group, while the latency of the first peak was shortened (MD = 0.061 ms, P = 0.040). HE staining showed more integrity in transected spinal cords in cells transplanted groups.</p><p><b>CONCLUSION</b>Transplanted tanycytes can support the regeneration of transected spinal cords in rats.</p>