Studies on bioassay-guided anti-inflammatory fraction in bark of Albizia julibrissin combined determination with LC-MS-MS / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 2021-2025, 2007.
Article
в Zh
| WPRIM
| ID: wpr-307539
Ответственная библиотека:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To search the anti-inflammatory fraction of Albizia julibrissin.</p><p><b>METHOD</b>Inflammatory model of Kunming mice ear edema induced by croton oil and determination combined with the LC-MS-MS-guided fractionation and isolation were used.</p><p><b>RESULT</b>The n-butanol fraction (AJ-B) obtained from the ethanolic extract of the Cortex albiziae was the major active fraction. The lignan glycosides fraction (AJ-B-1), which was further isolated from AJ-B, showed significant anti-inflammatory activity and exhibited dose-dependent relationship in the dose of 5 to 20 mg x kg(-1).</p><p><b>CONCLUSION</b>The method of bioassay-guided fractionation and isolation combined with the LC-MS-MS determination may be of benefit to the logical studies on the bioactive fractions or constituents of traditional Chinese materia medica.</p>
Полный текст:
1
База данных:
WPRIM
Основная тема:
Plants, Medicinal
/
Biological Assay
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Croton Oil
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Drugs, Chinese Herbal
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Chemistry
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Anti-Inflammatory Agents, Non-Steroidal
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Chromatography, High Pressure Liquid
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Lignans
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Plant Bark
/
Albizzia
Пределы темы:
Animals
Язык:
Zh
Журнал:
China Journal of Chinese Materia Medica
Год:
2007
Тип:
Article