Volume changes of cortical and subcortical reward circuitry in the brain of patients with type 2 diabetes mellitus / 南方医科大学学报
Journal of Southern Medical University
; (12): 1265-1272, 2013.
Article
в Zh
| WPRIM
| ID: wpr-319431
Ответственная библиотека:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To elucidate the volume changes of cortical and subcortical reward circuitry in patients with type 2 diabetes mellitus.</p><p><b>METHODS</b>High-resolution three-dimensional T1-weighted fast spoiled gradient recalled echo MRI images were obtained from 16 patients with type 2 diabetes mellitus and 16 normal controls, and 11 type 2 diabetic patients also received the same MRI scans after insulin therapy for 1 year. Volumetric analysis was performed and analysis of covariance and paired t test were applied.</p><p><b>RESULTS</b>A decreased volume was found in the left insular lobe, left nucleus accumbens area, right hippocampus, putamen and amygdala in type 2 diabetic patients compared with normal controls (P<0.05). After insulin therapy for 1 year, an increased volume of bilateral cortical reward structures was observed (left, 33.65∓3.66 ml; right, 33.35∓4.25 ml) compared the baseline level (left, 31.45∓2.90 ml; right, 31.12∓2.97 ml) in diabetic patients (P<0.05). No significant volume change in the bilateral basal ganglia structures was found after insulin therapy for 1 year (P>0.05), and bilateral ventral diencephalon area showed an increased volume after the treatment (left, 3.26∓0.68 ml; right, 3.20∓0.78 ml) compared with the baseline (left, 2.96∓0.76 ml; right, 2.82∓0.90 ml)(P<0.05).</p><p><b>CONCLUSION</b>Type 2 diabetic patients have a decreased volume of the cortical and subcortical reward circuitry, and insulin therapy can reverse such changes and improve the damage of reward circuitry.</p>
Полный текст:
1
База данных:
WPRIM
Основная тема:
Pathology
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Magnetic Resonance Imaging
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Cerebral Cortex
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Entorhinal Cortex
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Therapeutic Uses
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Diabetes Mellitus, Type 2
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Drug Therapy
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Insulin
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Nucleus Accumbens
Пределы темы:
Aged
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Female
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Humans
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Male
Язык:
Zh
Журнал:
Journal of Southern Medical University
Год:
2013
Тип:
Article