Clinical efficacy of immunotherapy of dendritic cell and cytokine-induced killer cell combined with chemotherapy for treatment of multiple myeloma / 中华血液学杂志
Chinese Journal of Hematology
; (12): 1000-1003, 2012.
Article
в Zh
| WPRIM
| ID: wpr-323505
Ответственная библиотека:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>This research was aimed to evaluate the immune mechanism and clinical effect of immunotherapy of dendritic cells (DC) and cytokine-induced killer cell (CIK) combined with chemotherapy on multiple myeloma (MM).</p><p><b>METHODS</b>60 patients with MM were randomly divided into two groups. 30 patients in chemotherapy group were treated by chemotherapy only, 30 patients in joint group were treated by adoptive immunotherapy (DC-CIK) combined with chemotherapy. A variety of immunological indexes (Hsp70, Th1/Th2, TGF-β) of all patients before and after chemotherapy were recorded; Also the clinical outcomes between two groups were compared.</p><p><b>RESULTS</b>After chemotherapy, the immunological indexes of all patients were better than those of before chemotherapy (P < 0.05); After treatment, quality of life, clinical index and survival in joint group were better than in chemotherapy group (P < 0.05).</p><p><b>CONCLUSION</b>Chemotherapy could break the immunosuppression of MM and improve the anti-tumor response of DC-CIK; Chemotherapy and DC-CIK may have synergistic effect for MM.</p>
Полный текст:
1
База данных:
WPRIM
Основная тема:
Therapeutics
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Dendritic Cells
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Antineoplastic Combined Chemotherapy Protocols
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Immunotherapy, Adoptive
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Treatment Outcome
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Combined Modality Therapy
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Therapeutic Uses
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Allergy and Immunology
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Cytokine-Induced Killer Cells
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Multiple Myeloma
Пределы темы:
Adult
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Aged
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Female
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Humans
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Male
Язык:
Zh
Журнал:
Chinese Journal of Hematology
Год:
2012
Тип:
Article