Epidemiology and antimicrobial resistance of clinical isolates about hospital infection from patients with hematological diseases / 中华血液学杂志
Chinese Journal of Hematology
; (12): 994-999, 2012.
Article
в Zh
| WPRIM
| ID: wpr-323506
Ответственная библиотека:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the epidemiology and antibiotic resistance of isolates from hospitalized patients with hematological disease from 2005 to 2011.</p><p><b>METHODS</b>A total of 1453 bacterial strains were isolated from patients with hematological disease from January 2005 to December 2011. Antimicrobial susceptibility testing was performed by micro-dilution method.</p><p><b>RESULTS</b>(1) The majority of the bacterial strains were respiratory passage examples (57.5%). The portage of blood examples in our division (13.60%) was higher than of whole hospital (6.26%), with lower positive rate of bacterial culture (52.37%) than of whole hospital (60.24%). Chemotherapy-induced agranulocytosis was the main reason for hospital infection. 578 (39.8%) bacterial strains were gram positive, and 875 (60.2%) gram negative bacillus. Staphylococcus epidermidis strains and glucose nonfermenters had a tendency of ascensus. (2) Methicillin resistant staphylococcus aureus (MRSA) accounted for 72.8% antibiotic resistance. Detection rates of ESBLs in Escherichia coli and Klebsiella pneumoniae were 18.9% and 10.4%, respectively. (3) No obvious changes of antimicrobial resistances of Staphylococcus and Enterococcus were observed during these years. The Enterobacteriaceae strains showed lowest resistance rates to Carbapenems, next to Cefoperazone/sulbactam and Piperacillin/tazobactam. But the resistance rates of Escherichia coli to Cefepime and Ceftazidime were gradually increasing during the past years. Pseudomonas aeruginosa and Acinetobacter baumannii of glucose nonfermenters showed lowest resistance rates to Cefoperazone/sulbactam, but the resistance rate of Pseudomonas aeruginosa to Carbapenems increased.</p><p><b>CONCLUSIONS</b>Escherichia coli was the highest in quantity of gram negative bacillus and glucose nonfermenters had a tendency of ascensus. The resistance rates of Escherichia coli to Cefepime and Ceftazidime, Pseudomonas aeruginosa to Carbapenems were gradually increasing in the past years.</p>
Полный текст:
1
База данных:
WPRIM
Основная тема:
Pharmacology
/
Bacteria
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Microbial Sensitivity Tests
/
Cross Infection
/
Epidemiology
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Drug Resistance, Bacterial
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Drug Therapy
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Hematologic Diseases
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Microbiology
/
Anti-Infective Agents
Тип исследования:
Screening_studies
Пределы темы:
Adult
/
Aged
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Female
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Humans
/
Male
Язык:
Zh
Журнал:
Chinese Journal of Hematology
Год:
2012
Тип:
Article