Evaluation of detection of Epstein-Barr virus Rta/IgG in nasopharyngeal carcinoma / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
; (6): 285-287, 2009.
Article
в Zh
| WPRIM
| ID: wpr-325565
Ответственная библиотека:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>This study was aimed to investigate the clinical value of Epstein-Barr virus (EBV) Rta/IgG in the diagnosis of nasopharyngeal carcinoma (NPC).</p><p><b>METHODS</b>Serum samples derived from 211 untreated patients with NPC, 413 subjects including 203 non-NPC ENT patients and 210 healthy volunteers as control were examined for the presence of antibodies directed against Rta/IgG by using enzyme-linked immnunosorbent assay (ELISA). Receiver operating characteristic (ROC) curve was applied to perform methodical evaluation of this tumor marker.</p><p><b>RESULTS</b>The rA value median of Rta/IgG in NPC group was significantly higher than one in control group (P < 0.001). The area under ROC was 0.933. The sensitivity and specificity of this marker were 90.5% and 90.1%, respectively, when the best cutoff value was defined.</p><p><b>CONCLUSION</b>Rta/IgG detected with ELISA method is a new target of EBV, and may be one of important marker for NPC diagnosis.</p>
Полный текст:
1
База данных:
WPRIM
Основная тема:
Virology
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Blood
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Immunoglobulin G
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Carcinoma
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Case-Control Studies
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Trans-Activators
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Nasopharyngeal Neoplasms
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Immediate-Early Proteins
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Herpesvirus 4, Human
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Epstein-Barr Virus Infections
Тип исследования:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
Пределы темы:
Adolescent
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Adult
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Aged
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Aged80
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Child
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Female
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Humans
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Male
Язык:
Zh
Журнал:
Chinese Journal of Experimental and Clinical Virology
Год:
2009
Тип:
Article