Effect of safflower injection on cardiac energy charge and anti-apoptosis gene bcl-2 in rats' heart / 中国中西医结合杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the effect of safflower injection (SI) in protecting heart, and on energy charge and anti-apoptosis gen bcl-2 in cardiac tissue.</p><p><b>METHODS</b>Rats' Langendorff isolated heart infused model was used in the experiment to study the effect of SI by measuring the cardiac function, energy charge and bcl-2 expression of the cultured heart in the modified Euro-Collins (mEC) heart preserving liquid with or without addition of SI.</p><p><b>RESULTS</b>As compared with the control, SI showed the effects of improving functions of cardiac contraction and dilation, increasing coronary blood flow, and strengthening the bcl-2 protein expression.</p><p><b>CONCLUSION</b>SI has excellent effect in protecting heart.</p>