The effect of chimonin on collagen metabolism of pulmonary arterioles in chronic hypoxic rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 217-221, 2010.
Article
в Zh
| WPRIM
| ID: wpr-340189
Ответственная библиотека:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect and mechanism of chimonin on pulmonary arterioles I and III type collagen metabolism in pulmonary hypertension rats induced by chronic hypoxic hypercapnia.</p><p><b>METHODS</b>Thirty-six Sprague-Dawley rats were randomly divided into three groups: normal control group(A), hypoxic hypercapnic group(B), hypoxic hypercapnia + chimonin group(C). Collagen I, III and their mRNA, Blood CO concentration (COHb%), activity of HO-1 in blood serum and lung homogenate, content of hydroxyproline in lung homogenate, pulmonary arteriole micromorphometric index were observed.</p><p><b>RESULTS</b>Hypoxic hypercapnic rats's mPAP, Hyr of lung homogenate, content of I type collagen and I type collagen mRNA in pulmonary arterioles, were significantly higher than those in control group, pulmonary vessel remodeling of hypoxic hypercapnic rats was significant, those changes in hypercapnia + chimonin group were significantly lower than those in hypoxic hypercapnic group. Blood CO concentration, activity of HO-1 in blood serum and lung homogenate in rats of hypoxic hypercapnic rats were significantly higher than those of control group, and those of hypercapnia + chimonin group were even higher than hypoxic hypercapnic group (P < 0.01). There was no significant difference in mCAP, content of III type collagen and their mRNA in three groups (P > 0.05).</p><p><b>CONCLUSION</b>Chimonin can reduce pulmonary hypertension and pulmonary vessel remodeling induced by hypoxic hypercapnia through inhibiting proliferation of collagen I, the mechanism maybe is up regulating endogenous carbon monoxide system.</p>
Полный текст:
1
База данных:
WPRIM
Основная тема:
Pharmacology
/
Arterioles
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Carbon Monoxide
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Drugs, Chinese Herbal
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Chronic Disease
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Rats, Sprague-Dawley
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Collagen Type I
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Collagen Type III
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Hypercapnia
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Hypertension, Pulmonary
Пределы темы:
Animals
Язык:
Zh
Журнал:
Chinese Journal of Applied Physiology
Год:
2010
Тип:
Article