Preventive efficacy of ondansetron and granisetron for postoperative nausea and vomiting in high risk patients / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 445-448, 2011.
Article
в Zh
| WPRIM
| ID: wpr-341386
Ответственная библиотека:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To compare the efficacy of ondansetron and granisetron in the prevention of postoperative nausea and vomiting (PONV) in high-risk patients.</p><p><b>METHODS</b>Totally 200 patients with three key risk factors for PONV (female, non-smoking and postoperative opioid use) were equally randomized into ondansetron group and granisetron group. Ondansetron (4 mg) or granisetron (3 mg) was intravenously administered upon the completion of surgery. The episodes of nausea and vomiting were observed for 24 hours after surgery.</p><p><b>RESULTS</b>A significantly greater proportion of patients in granisetron group achieved a complete response (i.e., no PONV or rescue medication) during the first 24 hours postoperatively versus those in ondansetron group (62.6% vs. 46.9%, respectively; P=0.048). There were no significant differences in terms of postoperative nausea incidences (42.9% vs. 34.3%, respectively), postoperative vomiting incidences (25.5% vs. 20.2%, respectively) and postoperative rescue anti-emetics incidences (19.4% vs. 15.2%, respectively) (P>0.05).</p><p><b>CONCLUSION</b>Granisetron is more effective than ondansetron in preventing PONV in high-risk patients during the first 24 hours postoperatively.</p>
Полный текст:
1
База данных:
WPRIM
Основная тема:
Double-Blind Method
/
Treatment Outcome
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Ondansetron
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Granisetron
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Postoperative Nausea and Vomiting
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Therapeutic Uses
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Antiemetics
Тип исследования:
Clinical_trials
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Etiology_studies
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Risk_factors_studies
Пределы темы:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
Язык:
Zh
Журнал:
Acta Academiae Medicinae Sinicae
Год:
2011
Тип:
Article