Anti-tumor activities and apoptotic mechanism of ribosome-inactivating proteins / 癌症
Chinese Journal of Cancer
; (12): 325-334, 2015.
Article
в En
| WPRIM
| ID: wpr-349588
Ответственная библиотека:
WPRO
ABSTRACT
Ribosome-inactivating proteins (RIPs) belong to a family of enzymes that attack eukaryotic ribosomes and potently inhibit cellular protein synthesis. RIPs possess several biomedical properties, including anti-viral and anti-tumor activities. Multiple RIPs are known to inhibit tumor cell proliferation through inducing apoptosis in a variety of cancers, such as breast cancer, leukemia/lymphoma, and hepatoma. This review focuses on the anti-tumor activities of RIPs and their apoptotic effects through three closely related pathways: mitochondrial, death receptor, and endoplasmic reticulum pathways.
Полный текст:
1
База данных:
WPRIM
Основная тема:
Plant Proteins
/
Ribosomes
/
Apoptosis
/
Endoplasmic Reticulum
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Receptors, Death Domain
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Ribosome Inactivating Proteins
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Mitochondria
/
Antineoplastic Agents
Пределы темы:
Animals
/
Humans
Язык:
En
Журнал:
Chinese Journal of Cancer
Год:
2015
Тип:
Article