Insight into early-phase trials for lung cancer in the United States / 癌症
Chinese Journal of Cancer
; (12): 288-294, 2015.
Article
в En
| WPRIM
| ID: wpr-349589
Ответственная библиотека:
WPRO
ABSTRACT
<p><b>INTRODUCTION</b>Few data have been published comparing early-phase trials for lung cancer between China and the United States (US). This study was to investigate the differences of phase 1 trials for lung cancer between these two countries.</p><p><b>METHODS</b>In 2014, a cross-sectional survey was conducted to compare phase 1 trials for lung cancer between the Guangdong Lung Cancer Institute (GLCI), the University of Wisconsin Carbone Cancer Center (UWCCC), and the University of Texas MD Anderson Cancer Center (MDACC).</p><p><b>RESULTS</b>We found that the GLCI had a lower percentage of phase 1 lung cancer trials than the MDACC in December 2014 (23.8% [5/21] vs. 59.8% [28/47], P = 0.006) and the UWCCC in September 2014 (16.7% [3/18] vs. 34.8% [8/23], P = 0.345). Descriptive analyses were performed for early-phase trials conducted by the Cancer Therapy Evaluation Program at the National Cancer Institute (CTEP/NCI), the MDACC, and the Chinese Thoracic Oncology Group (CTONG). There were 149 ongoing early-phase trials in the Department of Investigational Cancer Therapeutics (Phase 1 program) at the MDACC in October 2014. In contrast, no phase 1 trials had been initiated by the CTONG since its establishment in 2007.</p><p><b>CONCLUSIONS</b>These data suggest that a significantly higher percentage of phase 1 trials for lung cancer were conducted in the US than in China. Early-phase oncology trials with robust preclinical data had a higher chance of being approved by the Investigational Drug Branch at the CTEP/NCI. Given the importance of early-phase oncology trials in developing innovative cancer medicines, such studies should be highly encouraged and strategically funded in China.</p>
Полный текст:
1
База данных:
WPRIM
Основная тема:
United States
/
China
/
Cross-Sectional Studies
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Clinical Trials as Topic
/
Lung Neoplasms
Тип исследования:
Observational_studies
/
Prevalence_studies
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Risk_factors_studies
Пределы темы:
Humans
Страна как тема:
America do norte
/
Asia
Язык:
En
Журнал:
Chinese Journal of Cancer
Год:
2015
Тип:
Article