Preparation of Shuxiong micropellets by centrifugal granulation technology / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1147-1150, 2006.
Article
в Zh
| WPRIM
| ID: wpr-356721
Ответственная библиотека:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To prepare shuxiong micropellets.</p><p><b>METHOD</b>Shuxiong micropellets were prepared by using a centrifugal granulator. The formulation composition and process factors were optimized investigated by adopting several indices such as size distribution, repose angle, bulk density and friability as indexes.</p><p><b>RESULT</b>The optimal process parameters were as follows. The ratio of fine intermediate product and MCC was 31 (w/w), the adhesive agent was 3% HMPC solution, the rotating rate of plate was 200 r x min(-1), the blower rate was 15 x 20 L x min(-1), the rate of air flow was 15 L x min(-1), the spray air pressure was 0.5 MPa, the rotating of spray solution pump was 5-25 r x min(-1) and the rotating rate of powder feed machine was 5-25 r x min(-1).</p><p><b>CONCLUSION</b>Under the optimal conditions, micropellets prepared by using centrifugal granulator hadpossessed prefect shape and surface characteristics and the yield of shuxiong pellets was 90.5%.</p>
Полный текст:
1
База данных:
WPRIM
Основная тема:
Particle Size
/
Phenols
/
Plants, Medicinal
/
Quinones
/
Cellulose
/
Centrifugation
/
Chalcone
/
Chemistry
/
Technology, Pharmaceutical
/
Ligusticum
Язык:
Zh
Журнал:
China Journal of Chinese Materia Medica
Год:
2006
Тип:
Article