Arylamine N-acetyltransferases: a new inhibitor of apoptosis in HepG2 cells / 浙江大学学报（英文版）（B辑：生物医学和生物技术）

ABSTRACT

<p><b>OBJECTIVE</b>To explore how arylamine N-acetyltransferases (NATs) is related to cell apoptosis.</p><p><b>METHODS</b>NAT activity in apoptotic HepG2 cells was measured using high performance liquid chromatography (HPLC); the apoptosis rate of HepG2 cells acted upon by an NAT inhibitor was measured using flow cytometry.</p><p><b>RESULTS</b>NAT activity was lowered in apoptotic HepG2 cells; apoptosis rate induced by camptothecin (CAM) increased after inhibition of NAT activity in HepG2 cells.</p><p><b>CONCLUSION</b>NAT can inhibit apoptosis in HepG2 cells.</p>