Long-term study of male rabbit urethral mucosa reconstruction using epidermal cell / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
; (6): 719-722, 2008.
Article
в En
| WPRIM
| ID: wpr-359918
Ответственная библиотека:
WPRO
ABSTRACT
<p><b>AIM</b>To investigate the transformation of characteristics of epidermal cells from foreskin which were used to reconstruct male rabbit anterior urethra in combination with acellular collagen matrices.</p><p><b>METHODS</b>In three rabbits, autologous foreskin epidermal cells were isolated, expanded in vitro, and seeded (inoculated) onto a tubular acellular collagen matrix, acquired from allogeneic rabbit bladder submucosa. A urethral mucosal defect was created, and urethral reconstruction was performed with the tubular acellular collagen matrix seeded with epidermal cells.</p><p><b>RESULTS</b>On gross examination at 12 months following the procedure, the mucosa of the urethral grafts appeared lubricous and smooth. Urethrography showed that a wide urethral caliber had been maintained without any sign of strictures. Histological examination showed a transitional cell layer in the graft without evidence of a margin between the graft and the host tissue at 12 months postoperatively.</p><p><b>CONCLUSION</b>Epidermal cells seeded onto acellular collagen matrices can be successfully used to reconstruct urethras that have defects and are transformed to transitional epithelial cells.</p>
Полный текст:
1
База данных:
WPRIM
Основная тема:
General Surgery
/
Urethra
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Urethral Stricture
/
Collagen
/
Cell Transplantation
/
Plastic Surgery Procedures
/
Cell Biology
/
Tissue Engineering
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Tissue Culture Techniques
/
Epidermis
Пределы темы:
Animals
Язык:
En
Журнал:
Asian Journal of Andrology
Год:
2008
Тип:
Article