The effectiveness of different-dose atorvastatin on soluble CD105,high sensitive-C reactive protein and heart rate turbulence in patients with acute coronary syndrome / 中国医师进修杂志
Chinese Journal of Postgraduates of Medicine
; (36): 14-17, 2011.
Article
в Zh
| WPRIM
| ID: wpr-384168
Ответственная библиотека:
WPRO
ABSTRACT
Objective To investigate the clinical effects and significance of different-dose atorvastatin on soluble CD105(sCD105),high sensitive-C reactive protein(hs-CRP)and the parameters of heart rate turbulence in patients with acute coronary syndrome(ACS). Methods One hundred and six ACS patients were divided into three groups by random digits table: control group(30 patients, routine treatment),treatment group Ⅰ(38 patients, routine treatment + atorvastatin 20 mg), and treatment group Ⅱ(38patients, routine treatment + atorvastatin 40 mg). All patients were treated for 4 weeks. The levels of serum sCD105,hs-CRP,and the parameters of heart rate turbulence before and after treatment. Results Before treatment, the levels of turbulence onset(TO), turbulence slope(TS),sCD105 and hs-CRP in three groups had no significant difference(P > 0.05). After treatment, TO,sCD105 and hs-CRP decreased significantly,and TS increased significantly(P< 0.05 or < 0.01). The change amplitude of treatment group Ⅱ was the most obvious, and the levels of above mentioned index showed significantly difference compared with that of treatment group Ⅰ[TO:(0.22 ±0.18)% vs.(0.66 ± 0.23)%;TS:(6.22 ±0.83)ms/RR interval(RRI)vs.(3.90 ±0.73)ms/RRI;sCD105:(1.65 ±0.43)mg/L vs.(2.92 ±0.50)mg/L;hs-CRP:(1.68 ±0.55)mg/L vs.(2.08±0.61)mg/L](P <0.01). Correlation analysis showed the levels of sCD105 and hs-CRP had significantly positive correlation with TO(P < 0.01)and had negative correlation with TS(P < 0.01).Conclusions The atorvastatin treatment in patients with ACS may stabilize coronary vascular endothelial cells and atherosclerotic plaque, and improve autonomic nerve function. Larger doses of atorvastatin may get more benefit.
Полный текст:
1
База данных:
WPRIM
Тип исследования:
Diagnostic_studies
Язык:
Zh
Журнал:
Chinese Journal of Postgraduates of Medicine
Год:
2011
Тип:
Article