Unrelated stem cell transplantation after reduced-intensity conditioning plus rituximab for Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis with CNS involvement / 소아과
Korean Journal of Pediatrics
; : 725-729, 2009.
Article
в En
| WPRIM
| ID: wpr-38547
Ответственная библиотека:
WPRO
ABSTRACT
Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) with central nervous system (CNS) involvement is usually fatal unless stem cell transplant (SCT) is offered. However, SCT with conventional intensity conditioning is associated with high transplant-related mortality. We describe our experience with unrelated SCTs after reduced-intensity conditioning (RIC) for patients with EBV-HLH with progressive CNS disease. This approach was associated with minimal toxicities and might be an effective option in patients with EBV-HLH with progressive CNS disease. Moreover, the addition of rituximab to RIC appears to be safe and effective in suppressing EBV in the patients with EBV-HLH.
Key words
Полный текст:
1
База данных:
WPRIM
Основная тема:
Stem Cells
/
Central Nervous System
/
Central Nervous System Diseases
/
Herpesvirus 4, Human
/
Transplants
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Stem Cell Transplantation
/
Lymphohistiocytosis, Hemophagocytic
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Antibodies, Monoclonal, Murine-Derived
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Rituximab
Пределы темы:
Humans
Язык:
En
Журнал:
Korean Journal of Pediatrics
Год:
2009
Тип:
Article