Experimental study on bystander effects K562 cells induced by ionizing radiation / 中华放射医学与防护杂志
Chinese Journal of Radiological Medicine and Protection
; (12): 20-22, 2009.
Article
в Zh
| WPRIM
| ID: wpr-396234
Ответственная библиотека:
WPRO
ABSTRACT
Objective To study the bystander effects and associated mechanisms through irradiated conditioned medium(1CM). Methods Natural kilhr(NK) cells were obtained from peripheral blood samples. ICM irradiated with different doses of 60Coγ-rays was used for culturing K562 cell strain. The degree of injury of K562cells by activated NK cells was observed, as well as the apoptosis frequency of K562 cell was investigated. Results Severe injury was induced in K562 cells cultured in ICM than the control (sham-irradiated) as shown by increased sensitivity to NK cells (P < 0.05). The apoptosis frequency of K562 cell was increased significantly compared with the control cells (P < 0.05). Conclusions The bystander effect induced by irradiation is existent. ICM can trigger the bystander effect on K562 cell strains.
Полный текст:
1
База данных:
WPRIM
Язык:
Zh
Журнал:
Chinese Journal of Radiological Medicine and Protection
Год:
2009
Тип:
Article