Application of NT-proBNP in the diagnosis of cardiovascular disease / 中华检验医学杂志

ABSTRACT

N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a good plasma marker for the diagnosis and differential diagnosis of the heart failure.For decompensated heart failure,the double-cut-point strategy including the diagnostic cut-off point and eliminated cut-off point was suggested,and the diagnostic cut-off point can be further divided according to age to further improve the diagnostic accuracy.If the patient's value was in gray interval,doctors should further analyzed the possible confounders,including age,renal function,BMI et al.Recently,more researches were carried out for NT-proBNP in patients with acute coronary syndrome,and some studies showed that its combination with troponin increased the diagnostic efficacy of acute myocardial infarction.The studies of NT-proBNP were still carried out in other areas including atrial fibrillation,cardiomyopathy,valvular disease,pulmonary embolism et al and had obtained the results of the beneficial clinical applications.