Effect of alpha thioctic acid combined with mecobalamin in patients with diabetic peripheral neuropathy / 中国医师进修杂志

ABSTRACT

Objective To evaluate the effect of alpha thioctic acid combined with mecobalamin in patients with diabetic peripheral neuropathy.Methods Ninety patients with diabetic peripheral neuropathy were divided into observation group and control group by random digits table method with 45 cases each.The patients in observation group received alpha thioctic acid combined with mecobalamin treatment,and patients in control group received alpha thioctic acid treatment only.All patients were treated for 3 weeks.The clinical manifestation and electromyography effects were observed and compared after treatment.Results The total effective rate in observation group was significantly higher than that in control group [93.3％(42/45) vs.55.6％ (25/45)],and there was statistical difference (P ＜ 0.05).The sensory conduction velocity of common peroneal nerve after treatment in observation group was significantly higher than that in control group [(49.5 ± 3.2) m/s vs.(40.2 ± 2.9) m/s],and there was statistical difference (P ＜ 0.05).The sensory conduction velocity of median nerve,the motor conduction velocity of median nerve and common peroneal nerve had no significant differences between two groups (P ＞ 0.05).No adverse reaction happened during and after treatment.Conclusion Alpha thioctic acid combined with mecobalamin may improve the clinical efficacy of patients with diabetic peripheral neuropathy.