Stress-up-regulated myocardial endothelin receptors are suppressed by chlo-robenzyltetrahydroberberine CPU86017 and its RS chiral isomer / 中国药科大学学报
Journal of China Pharmaceutical University
; (6): 374-379, 2009.
Article
в Zh
| WPRIM
| ID: wpr-480429
Ответственная библиотека:
WPRO
ABSTRACT
Aim: To investigate the changes of endothelin( ET) receptors by isoproterenol in myocardial cells, and the invervention effects of CPU86017 and its RS isomer. Methods: Primary cultures of neonatal rat cardiomyo-cytes were prepared, and isoproterenol was added to each group for modeling, followed by drug interventions with propranolol, CPU86017 and RS chiral isomer respectively. Results: The expressions of ET_A and ET_B were increased by isoproterenol, in which the level of ET_B was higher than ET_A . This phenomenon was adjusted to different degrees by using propranolol, CPU86017 and RS chiral isomer in a dosage-relevant manner. The infervention effect of RS isomer was better than that of CPU86017 at the high dosage( 10 μmol/L). Conclusion: The cardiovascular effects of CPU86017 and RS chiral isomer could be correlative to the inhibition of the over-expressions of ET_A and ET_B.
Полный текст:
1
База данных:
WPRIM
Язык:
Zh
Журнал:
Journal of China Pharmaceutical University
Год:
2009
Тип:
Article