Analysis of Plasma Levels of Nuclear Factor-κB in Patients With Left-to-right Shunt Congenital Heart Disease Combining Pulmonary Arterial Hypertension / 中国循环杂志
Chinese Circulation Journal
; (12): 885-887, 2016.
Article
в Zh
| WPRIM
| ID: wpr-503836
Ответственная библиотека:
WPRO
ABSTRACT
Objective:
To explore the impact of nuclear factor-kappa B (NF-κB) in patients with left-to-right shunt congenital heart disease (CHD) combining pulmonary arterial hypertension (PAH) and its clinical signiifcance.Methods:
A total of 78 relevant patients were enrolled in this study. According to mean pulmonary artery pressure (mPAP) measured during operation, the patients were divided into 4 groups Non-PAH group, the patients with mPAP≤25 mmHg,n=20, Mild PAH group, 25 mmHg mPAP≤35 mmHg,n=21, Moderate PAH group, 35 mmHg45 mmHg,n=23. 2 mL pulmonary artery blood was taken from each patient and plasma level of NF-κB was measured by ELISA to study the relationship between NF-κB and mPAP.Results:
Pulmonary arterial plasma levels of NF-κB were increased accordingly as in Non-PAH group was (180.59 ± 10.16) ng/L, in Mild PAH group was (572.83 ± 34.80) ng/L, in Moderate PAH group was (980.85 ± 24.95) ng/L and in Severe PAH group was (1 253.4 ±130.8) ng/L, allP<0.01; NF-κB level was positively related to mPAP (r=0.856,P<0.01).Conclusion:
Plasma level of NF-κB was involved in the pathological physiology process of left-to-right shunt CHD combining PAH, it couldbe used as one of the references for distinguishing the severity of PAH and for monitoring the dynamic changes of PAH in relevant patients.
Полный текст:
1
База данных:
WPRIM
Язык:
Zh
Журнал:
Chinese Circulation Journal
Год:
2016
Тип:
Article