The Percutaneous Permeability of Methoxypsoralen Liposomal Gel / 中国药房
China Pharmacy
; (12)2001.
Article
в Zh
| WPRIM
| ID: wpr-521624
Ответственная библиотека:
WPRO
ABSTRACT
OBJECTIVE:
To study the percutaneous permeability of methoxypsoralen liposomal gelMETHODS:
The preparations were applied on the rat skin in vitro and in vivo with common gel and Mingbailing tincture as control,and the drug concentrations in the receiver,skin,blood and other organs were determined by RP-HPLCRESULTS:
In vitro experiment,liposomal gel showed the lowest percutaneous permeation rate and the highest retention in skin In vivo studies illuminated that the skin depositions of drug encapsulated in liposome was(4 37?0 91) and (3 36?0 58) times those of the common gel and tincture respectivelyCONCLUSION:
Methoxypsoralen liposomal gel showed an evident targeting effect on skin
Полный текст:
1
База данных:
WPRIM
Язык:
Zh
Журнал:
China Pharmacy
Год:
2001
Тип:
Article