Repair of peripheral nerve defects using acellular allogeneic nerve grafting combined with exogenous basic fibroblast growth factor / 中华创伤杂志

ABSTRACT

Objective To evaluate the long term effect of acellular allogeneic nerve grafting combined with exogenous basic fibroblast growth factor (bFGF) in peripheral nerve repair. Methods Sixteen big-ear Japanese rabbits were divided into experimental and control groups randomly. In the experimental group, 3 cm-long acellular allogeneic nerves from New Zealand rabbit were used to bridge the rabbit tibial nerve defects; and 1 ml bFGF solution was given from the second day once daily for 2 weeks and twice a week for another 6 weeks after surgery. In the control group, normal saline solution was given. Morphological and functional results were evaluated 20 weeks after the nerve repair. Results The recovery rates of the evoked potential and the nerve conduction velocity in the experimental group were 67.59%?29.63% and 59.79%?21.11%, respectively, significantly higher than that (49.07%? 15.74% and 36.85%?18.69% respectively) in the control group (P