The effect of cyclosporin A on CD4~+CD25~+T cells in TCR-transgenic DO11.10 mice immunized with OVA / 中国免疫学杂志
Chinese Journal of Immunology
; (12)2001.
Article
в Zh
| WPRIM
| ID: wpr-546520
Ответственная библиотека:
WPRO
ABSTRACT
Objective:
To study the effect of CsA on CD4+CD25+T cells from DO11.10 mice after immunization with OVA.Methods:
The amount of spleen CD4+CD25+T cells and Foxp3+T cells was detected by means of flow cytometry (FCM).Results:
After immunization with OVA,the ratios of CD4+CD25+T cells to CD4+T cells and Foxp3+T cells to CD4+CD25+T cells elevated in spleen,but CsA significantly decreased the percentage of CD4+CD25+T cells and CD4+CD25+Foxp3+T cells under either naive state or immune reaction state.Conclusion:
CsA inhibits immune responses,while it also suppresses immune tolerance.
Полный текст:
1
База данных:
WPRIM
Язык:
Zh
Журнал:
Chinese Journal of Immunology
Год:
2001
Тип:
Article