Immunomodulatory Effects of Hypocrellin A on MHC-restricted Antigen Processing
Immune Network
; : 412-415, 2011.
Article
в En
| WPRIM
| ID: wpr-60131
Ответственная библиотека:
WPRO
ABSTRACT
Hypocrellin A has gained much attention in recent years due to its light-induced antitumor, antifungal and antiviral activities. Here we report that hypocrellin A exerts immunomodulatory effects on MHC-restricted presentation of antigen. Hypocrellin A inhibited class II-MHC restricted presentation of exogenous antigen, but not class I MHC-restricted presentation of exogenous antigen, in dendritic cells. Hypocrellin A also inhibited the cytosolic pathway of endogenous antigen presentation. However, hypocrellin A did not inhibit the expression of class I and class II MHC molecules on dendritic cells (DCs), the phagocytic activity of DCs, or the H-2K(b)-restricted presentation of a synthetic peptide, SIINFEKL. These results show that hypocrellin A differentially modulates the MHC-restricted antigen presentation pathways.
Key words
Полный текст:
1
База данных:
WPRIM
Основная тема:
Perylene
/
Quinones
/
Dendritic Cells
/
Antigen Presentation
/
Cytosol
Язык:
En
Журнал:
Immune Network
Год:
2011
Тип:
Article