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Immunomodulatory Effects of Hypocrellin A on MHC-restricted Antigen Processing
Immune Network ; : 412-415, 2011.
Article в En | WPRIM | ID: wpr-60131
Ответственная библиотека: WPRO
ABSTRACT
Hypocrellin A has gained much attention in recent years due to its light-induced antitumor, antifungal and antiviral activities. Here we report that hypocrellin A exerts immunomodulatory effects on MHC-restricted presentation of antigen. Hypocrellin A inhibited class II-MHC restricted presentation of exogenous antigen, but not class I MHC-restricted presentation of exogenous antigen, in dendritic cells. Hypocrellin A also inhibited the cytosolic pathway of endogenous antigen presentation. However, hypocrellin A did not inhibit the expression of class I and class II MHC molecules on dendritic cells (DCs), the phagocytic activity of DCs, or the H-2K(b)-restricted presentation of a synthetic peptide, SIINFEKL. These results show that hypocrellin A differentially modulates the MHC-restricted antigen presentation pathways.
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Полный текст: 1 База данных: WPRIM Основная тема: Perylene / Quinones / Dendritic Cells / Antigen Presentation / Cytosol Язык: En Журнал: Immune Network Год: 2011 Тип: Article
Полный текст: 1 База данных: WPRIM Основная тема: Perylene / Quinones / Dendritic Cells / Antigen Presentation / Cytosol Язык: En Журнал: Immune Network Год: 2011 Тип: Article