Clinical analysis of 21 cases of anaplastic thyroid carcinoma / 国际外科学杂志

ABSTRACT

Objects To investigate the therapeutic schemes and factors that influences survival of the patients with anaplastic thyroid carcinoma (ATC).Methods The clinical data of 21 cases with ATC admitted in First Affiliated Hospital of Zhengzhou University from Jan.2009 to Nov.2013 were analyzed retrospectively.Explored patients survival rates according to the age,the gender,the white cell count,the therapeutic scheme (surgery plus radiotherapy,surgery alone),the operation mode (radical surgery,palliative surgery).SPSS 21.0 software was used for statistical processing,and Kaplan-Meier was used to calculate the survival rate,the Log-Rank was uesd for the difference test.Results The overall survival rates of the 1-,3-and 5-year were 42.9％,28.6％,and 4.8％ respectively.A significant difference had been found in the 5-year survival rate between the group of surgery coupled with postoperative chemoradiotherapy(7.1％) and the group of surgery alone(0) (P ＜ 0.05).So it was the same between the group of radical surgery (8.3％) and the group of palliative surgery (0) (P ＜0.05).And a clear break point of the white blood cell count(1.0 × 1010/L) had demonstrated the significant difference of the 5-year survival rate between the groups of both sides,while the lower group (11.1％) could be much higher (P ＜0.05).Conclusions The prognosis of ATC is very poor,and the group the patients with higher white cell count (≥ 1.0 × 1010/L) can be even poorer.Compared with palliative surgery,radical surgery can improve the survival rate.Compared with surgery alone,surgery coupled with postoperative chemoradiotherapy can improve the survival rate signifantltly.