Effects of Wnt3a and Wnt5a signaling pathway switching on hematopoietic stem cells senescence / 基础医学与临床
Basic & Clinical Medicine
; (12): 703-707, 2018.
Article
в Zh
| WPRIM
| ID: wpr-693968
Ответственная библиотека:
WPRO
ABSTRACT
Hematopoietic stem cells(HSCs)senescence is an important reason of hematopoietical and immunologi-cal function senescence.It also is play a key role during aging-related diseases development.Under certain condi-tions,the activation of classical Wnt 3a/β-catenin is in favour of maintains polarity and young states of HSCs,self-renewing,proliferation and differentiation potency.Switching to the non-classical Wnt5a pathway,further activation of Cdc42 protein and others can promote HSCs ageing,and indirectly inhibits Wnt3a/beta-catenin pathway.The in-tervention of two Wnt signaling pathways switching and mechanism,not only can illustrate the mechanism of HSCs aging,but also clear how to slow down ageing.This could provide a new strategy on the solution of age-related dis-eases and keeping a young state.
Полный текст:
1
База данных:
WPRIM
Язык:
Zh
Журнал:
Basic & Clinical Medicine
Год:
2018
Тип:
Article