Surveillance of antimicrobial resistance in Liuzhou Workers' Hospital in Guangxi during 2016 / 中国感染与化疗杂志

ABSTRACT

Objective To investigate the antimicrobial resistance of bacterial isolates in Liuzhou Workers' Hospital in Guangxi during 2016.Methods Kirby-Bauer method or automated systems was employed to study the antimicrobial susceptibility.The data were analyzed according to CLSI 2015 breakpoints.Results A total of 5 485 bacterial strains were isolated from 48 908 specimens in Liuzhou Workers' Hospital during 2016,of which gram negative organisms accounted for 70.3％ and gram positive cocci 29.7％.The prevalence of methicillin-resistant strains was 18.3％ (83/454) in S.aureus and 72.5％ (232/320) in coagulase negative Staphylococcus.No staphylococcal strains were found resistant to vancomycin or linezolid.Of the 207 strains of non-meningitis S.pneumoniae,181 (87.4％) were isolated from children and 26 (12.6％) from adults.One E.faecium strain was identified as resistant to vancomycin.The prevalence of ESBLs-producing strains was 49.0％ (619/1 263) in E.coli and 31.8％ (202/636) in Klebsiella spp.Enterobacteriaceae strains were still highly susceptible to carbapenem antibiotics.Overall,0.6％ (14/2 326) and 1.5％ (36/2 326) of the Enterobacteriaceae strains were resistant to imipenem and meropenem,respectively.Conclusions Antibiotic-resistant bacterial strains,especially carbapenem-resistant Enterobacteriaceae,are posing an increasing threat to clinical practice.Special attention should be paid to ongoing surveillance of local antimicrobial resistance to inform standardized anti-infective treatment.