Pharmacokinetics and Tissue Distribution of Curcumin in Turmeric Capsules in Rats / 中国药师
China Pharmacist
; (12): 65-68, 2018.
Article
в Zh
| WPRIM
| ID: wpr-705452
Ответственная библиотека:
WPRO
ABSTRACT
Objective:To study the pharmacokinetics and tissue distribution characteristics of curcumin in turmeric capsules in rats.Methods:SD rats were given the capsules at the dose of 5 g· kg-1 , and plasma, liver, kidney, stomach and small intestine were withdrawn.Curcumin was determined by HPLC .Results:The results showed that the linear range of curcumin was 0.1-10μg· ml-1 .The metabolic results in vivo showed that t1/2 was (25.13 ±5.63) h, tmax was 0.50 h, Cmax was (0.44 ±0.01)μg· ml-1 , and AUC0-t was (2.11 ±0.04)μg· ml-1 · h.Meanwhile, curcumin could be detected out in gastrointestinal tract , liver and the other or-gans.Conclusion:Turmeric capsules can make curcumin rapidly absorbed and effectively distributed in various tissues of rats .The re-sults provide evidence for the clinical medication .
Полный текст:
1
База данных:
WPRIM
Язык:
Zh
Журнал:
China Pharmacist
Год:
2018
Тип:
Article