Association between Plasma Pentraxin 3 Levels and Bone Mineral Density in Elderly Koreans: the Dong-gu Study
Journal of Korean Medical Science
; : e165-2018.
Article
в En
| WPRIM
| ID: wpr-714823
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ABSTRACT
BACKGROUND: We investigated the association between pentraxin 3 (PTX3), a novel inflammatory marker, and bone mineral density (BMD) in the general Korean population. METHODS: We selected a sub-cohort of 1,440 subjects (757 men and 683 women) from participants in the community-based Dong-gu Study. The mean age was 66.0 ± 8.1 years for men and 63.7 ± 7.9 years for women. The plasma PTX3 levels were measured using an enzyme-linked immunosorbent assay, and BMD was measured in the femoral neck and lumbar spine using dual-energy X-ray absorptiometry. Linear regression analyses were used to evaluate the association between the plasma PTX3 levels and BMD. RESULTS: PTX3 was inversely associated with the BMD of the lumbar spine (P = 0.010) and femoral neck (P < 0.001) in men but not in women. For men, the association with the BMD of the femoral neck remained after adjustment for multiple comparison (P = 0.020). CONCLUSION: This study suggests that PTX3 levels might be inversely associated with BMD in elderly men.
Key words
Полный текст:
1
База данных:
WPRIM
Основная тема:
Plasma
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Spine
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Enzyme-Linked Immunosorbent Assay
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Absorptiometry, Photon
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Bone Density
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Linear Models
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Femur Neck
Пределы темы:
Aged
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Female
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Humans
/
Male
Язык:
En
Журнал:
Journal of Korean Medical Science
Год:
2018
Тип:
Article