Effects of α-asarone on Proliferation and Differentiation of Neural Progenitor Cells / 체질인류학회지
Korean Journal of Physical Anthropology
; : 41-49, 2018.
Article
в Ko
| WPRIM
| ID: wpr-715129
Ответственная библиотека:
WPRO
ABSTRACT
This study investigated whether α-asarone could promote proliferation and differentiation of neural progenitor cells into the neuronal cell types in in vitro and ex vivo studies. For in vitro assay, neural progenitor cells were isolated from fetal cerebral cortex (E15) and checked cell proliferation rate and neural progenitor cell marker in neurospheres. Treatment of α-asarone, particularly at a concentration of 3 µM, promoted the proliferation of neural progenitor cells and effectively differentiated neural progenitor cells into neurons. For ex vivo assay, a hippocampi slice culture system from 7 day postnatal rat fetuses was used. Although slight tissue damage was observed in the hippocampus after the high concentration (100 µM) of α-asarone, however, α-asarone enhanced the proliferation of neural progenitor cells in dentate gyrus region and also effectively differentiated into neuroblast at concentration of 30 µM. Consequently, α-asarone promotes the proliferation of neural progenitor cells and effectively differentiates neural progenitor cells into neurons. Therefore, our results support the therapeutic benefits of α-asarone for treating neurodegenerative diseases.
Key words
Полный текст:
1
База данных:
WPRIM
Основная тема:
Stem Cells
/
In Vitro Techniques
/
Cerebral Cortex
/
Dentate Gyrus
/
Neurodegenerative Diseases
/
Cell Proliferation
/
Fetus
/
Hippocampus
/
Neurons
Пределы темы:
Animals
Язык:
Ko
Журнал:
Korean Journal of Physical Anthropology
Год:
2018
Тип:
Article