Variants in the Gene EBF2 Are Associated with Kawasaki Disease in a Korean Population
Yonsei Medical Journal
; : 519-523, 2018.
Article
в En
| WPRIM
| ID: wpr-715389
Ответственная библиотека:
WPRO
ABSTRACT
PURPOSE: Kawasaki disease (KD) is a mucocutaneous lymph node syndrome. It is mainly seen in young children under the age of five. KD is a multifactorial disorder that includes genetic variants. The present study investigated the association between KD and single nucleotide polymorphisms (SNPs) in the candidate gene early B cell factor 2 (EBF2), which is associated with inflammation markers. MATERIALS AND METHODS: An SNP analysis was performed by whole exon sequencing of the EBF2 gene. Our study comprised a total of 495 subjects (295 KD patients and 200 unrelated normal controls) from a Korean population. Tag SNPs were discovered using the Haploview program. Genotyping of the EBF2 gene was performed with the TaqMan® assay with real-time PCR methods. RESULTS: Polymorphism of rs10866845 showed a significant difference in allele frequency between KD patients and controls (p=0.040). The EBF2 gene polymorphisms were significantly associated with KD on logistic regression analysis. CONCLUSION: EBF2 gene variants can contribute to KD in the Korean population.
Key words
Полный текст:
1
База данных:
WPRIM
Основная тема:
Logistic Models
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Exons
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Polymorphism, Single Nucleotide
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Real-Time Polymerase Chain Reaction
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Gene Frequency
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Inflammation
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Mucocutaneous Lymph Node Syndrome
Тип исследования:
Prognostic_studies
/
Risk_factors_studies
Пределы темы:
Child
/
Humans
Язык:
En
Журнал:
Yonsei Medical Journal
Год:
2018
Тип:
Article