Effects of Tumor Necrosis Factor-alpha Inhibitors on the Incidence of Tuberculosis
Korean Journal of Clinical Pharmacy
; : 333-341, 2018.
Article
в En
| WPRIM
| ID: wpr-718925
Ответственная библиотека:
WPRO
ABSTRACT
OBJECTIVE:
Tumor necrosis factor-alpha (TNF-alpha) inhibitors are used as a treatment in various immune-mediated inflammatory diseases (IMIDs). Tuberculosis (TB) risk is reported in several meta-analyses in patients treated with TNF-alpha inhibitors. The purpose of this study is to collect, review, and evaluate the TB risk in TNF-alpha inhibitors according to IMIDs indications and between soluble-receptor TNF-alpha inhibitor and monoclonal-antibody TNF-alpha inhibitors.METHODS:
A systematic literature search on systematic reviews and meta-analyses was performed in PubMed, MEDLINE, Cochrane library, and EMBASE. We identified meta-analyses that evaluated TB infection risk of TNF-alpha inhibitors in IMIDs patients.RESULTS:
Thirteen meta-analyses including 41 study results were included in this umbrella review. IMIDs patients treated with TNF-alpha inhibitors had an increased risk of TB than control group (placebo with or without standard therapy patients) (relative risk ratio (RR) 2.057, 95% confidence interval (CI) 1.697 to 2.495). Among them, RA patients with TNF-alpha inhibitors had a higher risk of TB than control group (RR 1.847, 95% CI 1.385 to 2.464), and non-RA patients with TNF-alpha inhibitors had an increased risk of TB (RR 2.236, 95% CI 1.284 to 3.894). In subgroup analysis on TB risk between soluble-receptor TNF-alpha inhibitor and monoclonal-antibody TNF-alpha inhibitors in RA patients, the analysis indicated that monoclonal-antibody TNF-alpha inhibitors had higher risk of TB than solublereceptor TNF-alpha inhibitor (RR 2.880, 95% CI 1.730 to 4.792).CONCLUSION:
This umbrella review confirms that the risk of TB is significantly increased in TNF-alpha inhibitor treated patients compared to control group.Key words
Полный текст:
1
База данных:
WPRIM
Основная тема:
Arthritis, Rheumatoid
/
Tuberculosis
/
Odds Ratio
/
Incidence
/
Tumor Necrosis Factor-alpha
Тип исследования:
Clinical_trials
/
Etiology_studies
/
Incidence_studies
/
Prognostic_studies
Пределы темы:
Humans
Язык:
En
Журнал:
Korean Journal of Clinical Pharmacy
Год:
2018
Тип:
Article